Arrhythmias & electrophysiologyCohort study
Long-Term Outcomes and Safety of His-Purkinje Conduction System Pacing in China
- prospective registry-based study
- 5 Chinese centers
- multicenter
Authors' conclusion
CSP demonstrated long-term safety and stability. Subclassification of LBBAP enhances clinical precision, with LBBP capture yielding a higher positive clinical outcomes and LVSP with inferior outcomes, especially in cardiac resynchronization therapy patients.
Study context
- Population
- Patients receiving conduction system pacing at Chinese centers from 2019 to 2021enrolled, 3,167 successfully received conduction system pacing (CSP) · His bundle pacing (HBP) 557 · left bundle branch area pacing (LBBAP) 2,610
- Participants
- 3,336 patients
- Exposure
- HBP vs LBBAP, and LBBAP subclasses
- HBPn = 557
- LBBAPn = 2,610
Main finding
As reported in the abstract
LVEF improvement in patients with LBBB and heart failure with reduced ejection fraction
Left bundle branch pacing (LBBP)
+20.7%
HBP
+21.9%
Left ventricular septal pacing (LVSP)
+12.1%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Mortality or heart failure hospitalization | LVSP 33.3% · LBBP 8.6% · unclassified LBBAP 15.4% |
| Follow-up and LBBAP classification | LBBP share of LBBAP 84.2% · unclassified LBBAP share of LBBAP 12.5% · LVSP share of LBBAP 3.3% |
- Follow-up and LBBAP classification — mean follow-up
- 41.3 ± 14.0 months
Safety
| Outcome | Values | P value |
|---|---|---|
| Threshold increases ≥1 V/0.5 ms | HBP 5.03% · LBBAP 1.80% | P < 0.001 |
| Procedural complications (excluding threshold rise) | HBP 1.3% · LBBAP 1.3% |
Original publication
Long-Term Outcomes and Safety of His-Purkinje Conduction System Pacing in China. JACC Clin Electrophysiol. Published 19 March 2026. doi:10.1016/j.jacep.2026.01.037
Summarised from the published abstract; every number is checked against it