Valvular & structural heart disease
Long-Term Outcomes of Contemporary Balloon-Expandable Transcatheter Aortic Valve Replacement (TAVR) in Bicuspid Aortic Valve: A Propensity-Matched Comparison to Tricuspid
Authors' conclusion
In propensity score-matched patients undergoing TAVR with contemporary BEVs, long-term clinical outcomes, valve performance, and ascending aortic growth rate showed no statistically significant differences between bicuspid and tricuspid groups.
Study context
- Population
- Patients with native severe AS undergoing TAVR with contemporary balloon-expandable valves, August 2015 to December 2023
- Participants
- 3,393 patients · 515 matched pairs
- Exposure
- Bicuspid vs Tricuspid
- Outcome
- All-cause mortality
- Follow-up
- 5-year follow-up
Methodological detailspropensity-score matched
- Propensity-score matched
Main finding
As reported in the abstract
median follow-up 1,511 days (Q1-Q3: 937-1825 days)
- Bicuspid vs Tricuspid: P = 0.384
- 515 propensity score-matched pairs
Observational data: associations, not effects.
Further findings
HF rehospitalization · 5 years
P = 0.622
Stroke · 5 years
P = 0.618
Aortic valve reintervention · 5 years
P = 0.706
In-hospital death
P = 0.738
| Outcome | P value |
|---|---|
| Ascending aortic growth rate · 0.37 mm/y vs 0.31 mm/y | P = 0.578 |
| Valve hemodynamics: mean transvalvular gradient, effective orifice area, moderate or greater paravalvular leak · through 5 years · mean gradient 12.0 mm Hg vs 11.5 mm Hg | P = 0.863 |
| Valve hemodynamics: mean transvalvular gradient, effective orifice area, moderate or greater paravalvular leak · through 5 years · EOA 1.35 cm² vs 1.50 cm² | P = 0.084 |
| Valve hemodynamics: mean transvalvular gradient, effective orifice area, moderate or greater paravalvular leak · through 5 years · moderate or greater paravalvular leak 3.9% vs 5.6% | P = 0.578 |
Original publication
Long-Term Outcomes of Contemporary Balloon-Expandable TAVR in Bicuspid Aortic Valve: A Propensity-Matched Comparison to Tricuspid. JACC Cardiovasc Interv. Published 14 September 2026. doi:10.
Summarised from the published abstract; every number is checked against it