Long-Term Outcomes of Contemporary Balloon-Expandable TAVR in Bicuspid Aortic Valve

doi:10.1016/j.jcin.2026.06.015

Valvular & structural heart diseaseCohort study

Long-Term Outcomes of Contemporary Balloon-Expandable Transcatheter Aortic Valve Replacement (TAVR) in Bicuspid Aortic Valve

JACC Cardiovasc IntervPublished 14 Sep 2026

Retrospective cohort study
propensity-score matched

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Authors' conclusion

In propensity score-matched patients undergoing TAVR with contemporary BEVs, long-term clinical outcomes, valve performance, and ascending aortic growth rate showed no statistically significant differences between bicuspid and tricuspid groups.

Study context

Population: Patients with native severe AS undergoing TAVR with contemporary balloon-expandable valves, August 2015 to December 2023
Participants: 3,393 patients · 515 matched pairs

Exposure: Bicuspid vs Tricuspid
Outcome: All-cause mortality
Follow-up: 5-year follow-up

Main finding

As reported in the abstract

median follow-up 1,511 days (Q1-Q3: 937-1825 days)

Bicuspid vs Tricuspid: P = 0.384
515 propensity score-matched pairs

Observational data: associations, not effects.

Further findings

HF rehospitalization · 5 years

P = 0.622

Bicuspid8.5%

Tricuspid6.8%

Stroke · 5 years

P = 0.618

Bicuspid2.4%

Tricuspid2.6%

Aortic valve reintervention · 5 years

P = 0.706

Bicuspid0.7%

Tricuspid1.6%

In-hospital death

P = 0.738

Bicuspid0.8%

Tricuspid1.0%

Outcome	P value
Ascending aortic growth rate · 0.37 mm/y vs 0.31 mm/y	P = 0.578
Valve hemodynamics: mean transvalvular gradient, effective orifice area, moderate or greater paravalvular leak · through 5 years · mean gradient 12.0 mm Hg vs 11.5 mm Hg	P = 0.863
Valve hemodynamics: mean transvalvular gradient, effective orifice area, moderate or greater paravalvular leak · through 5 years · EOA 1.35 cm² vs 1.50 cm²	P = 0.084
Valve hemodynamics: mean transvalvular gradient, effective orifice area, moderate or greater paravalvular leak · through 5 years · moderate or greater paravalvular leak 3.9% vs 5.6%	P = 0.578

Original publication

Long-Term Outcomes of Contemporary Balloon-Expandable TAVR in Bicuspid Aortic Valve. JACC Cardiovasc Interv. Published 14 September 2026. doi:10.1016/j.jcin.2026.06.015

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Summarised from the published abstract; every number is checked against it