Valvular & structural heart diseaseCohort study
Long-Term Outcomes of Patients Requiring Pacemaker Implantation After Transcatheter Aortic Valve Replacement
- Prospective cohort study
- observational
- nationwide
- multicentre (19 centres)
Authors' conclusion
In this large nationwide registry, patients receiving PM implantation within 30 days after TAVR had significantly higher rates of overall and cardiovascular mortality up to 10 years.
Study context
- Population
- Patients undergoing transcatheter aortic valve replacement (TAVR) at 19 centres across Switzerland, February 2011 to June 2022 (SwissTAVI Registry)
- Participants
- 13,360 patients
- Exposure
- Pacemaker (PM) implantation within 30 days post-TAVR vs no PM
- PMn = 2,028
- Outcome
- All-cause and CV mortality
- Follow-up
- 1 year
Main finding
As reported in the abstract
Mortality
PM vs No PMAdjusted hazard ratio (95% CI)P value
all-cause mortality
1.15(1.05–1.26)
P = 0.002CV mortality
1.25(1.06–1.46)
P = 0.006Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| CV mortality, LVEF decline ≥10%, NYHA class III or IV · 1 year · after multivariable adjustment | 1.44 (1.35–1.54) | P < 0.001 | |
| 0.512Adjusted hazard ratio (log scale) |
All-cause and CV mortality · 5 and 10 years
- Higher all-cause and CV mortality with PM at 5- and 10-year follow-up
Original publication
Long-Term Outcomes of Patients Requiring Pacemaker Implantation After Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv. Published 1 April 2025. doi:10.1016/j.jcin.2025.03.028
Summarised from the published abstract; every number is checked against it