Long-Term Outcomes of Women With Peripartum Cardiomyopathy Having Subsequent Pregnancies
Authors' conclusion
Subsequent pregnancies in women with PPCM are associated with adverse events. The normalization of left ventricular function does not guarantee a favorable outcome in the SSPs.
Study context
- Population
- Women with peripartum cardiomyopathy (patients with peripartum cardiomyopathy (PPCM)) having subsequent pregnancies (SSPs); mostly African American, low socioeconomic backgroundof 137 PPCMs in registry
- Participants
- 45 women
- Exposure
- Recovery vs nonrecovery of LV function before subsequent pregnancy
- Recovery group (RG)n = 30reference
- Outcome
- Long-term survival (adverse outcomes) of SSPs
- Follow-up
- 5 years
Methodological detailsregistry
- Registry
Main finding
As reported in the abstract
Adverse outcomes
P = 0.04
Observational data: associations, not effects.
Further findings
All-cause mortality · 5 years
P = 0.25
Adverse outcomes and all-cause mortality · median follow-up 8 years
Adverse outcomes
P = 0.20
All-cause mortality
| Outcome | RG | NRG | P value | |
|---|---|---|---|---|
| Relapse PPCM · 5 years | 20.0% | Not reported in the abstract | P = 0.03 | NRG: not reported in the abstract |
Adverse outcomes and all-cause mortality · median follow-up 8 years
- Similar in nonrecovery group (NRG) and RG
Mean LVEF change with SSPs (overall)
- Mean LVEF decreased from 45.1% ± 13.7% to 41.2% ± 14.5%
- P = 0.009
Original publication
Long-Term Outcomes of Women With Peripartum Cardiomyopathy Having Subsequent Pregnancies. J Am Coll Cardiol. Published 4 July 2023. doi:10.
Summarised from the published abstract; every number is checked against it