Cardio-oncology & otherCohort study
Long-Term Outcomes of Women With Peripartum Cardiomyopathy Having Subsequent Pregnancies
- Retrospective cohort study
- registry
Authors' conclusion
Subsequent pregnancies in women with PPCM are associated with adverse events. The normalization of left ventricular function does not guarantee a favorable outcome in the SSPs.
Study context
- Population
- Women with peripartum cardiomyopathy (patients with peripartum cardiomyopathy (PPCM)) having subsequent pregnancies (SSPs); mostly African American, low socioeconomic backgroundof 137 PPCMs in registry
- Participants
- 45 women
- Exposure
- Recovery vs nonrecovery of LV function before subsequent pregnancy
- Recovery group (RG)n = 30reference
- Outcome
- Long-term survival (adverse outcomes) of SSPs
- Follow-up
- 5 years
Main finding
As reported in the abstract
Adverse outcomes
P = 0.04
Observational data: associations, not effects.
Further findings
All-cause mortality · 5 years
P = 0.25
Adverse outcomes and all-cause mortality · median follow-up 8 years
Adverse outcomes
P = 0.20
All-cause mortality
| Outcome | RG | NRG | P value |
|---|---|---|---|
| Relapse PPCM · 5 years | 20.0% | Not reported in the abstract | P = 0.03 |
Adverse outcomes and all-cause mortality · median follow-up 8 years
- Similar in nonrecovery group (NRG) and RG
Mean LVEF change with SSPs (overall)
- Mean LVEF decreased from 45.1% ± 13.7% to 41.2% ± 14.5%
- P = 0.009
Original publication
Long-Term Outcomes of Women With Peripartum Cardiomyopathy Having Subsequent Pregnancies. J Am Coll Cardiol. Published 4 July 2023. doi:10.1016/j.jacc.2023.04.043
Summarised from the published abstract; every number is checked against it