Coronary disease & ACSCohort study
Long-term PM2.5 component exposure, genetic susceptibility, and myocardial infarction risk
- Prospective cohort study
- Fine-Gray competing risk regression
- quantile-based g-computation
- polygenic risk score
Authors' conclusion
Chronic PM2.5 component exposure was linked to an increased MI risk, and genetic susceptibility may modify these associations.
Study context
- Population
- Participants free of CVD at baseline9,327 developed myocardial infarction (MI)
- Participants
- 452,693 participants
- Exposure
- Per IQR increase in long-term PM2.5 component exposure
- Outcome
- Incident MI (all-cause mortality as competing event)
- Follow-up
- Median 11.75 years
Main finding
As reported in the abstract
MI risk per IQR increase in PM2.5 component
Hazard ratio (95% CI)
black carbon
1.171(1.141–1.202)
ammonium
1.356(1.332–1.381)
nitrate
1.073(1.048–1.100)
sulphate
1.232(1.210–1.254)
Per IQR increase, as printed
Observational data: associations, not effects.
Further findings
Combined effects of PM2.5 components (quantile-based g-computation)
- Sulphate contributed most to the combined effects of PM2.5 components
Genetic susceptibility (polygenic risk score) × PM2.5 components
- Significant additive interactions and joint effects between genetic susceptibility and each PM2.5 component on MI risk
Original publication
Long-term PM2.5 component exposure, genetic susceptibility, and myocardial infarction risk. Eur J Prev Cardiol. Published 30 July 2025. doi:10.1093/eurjpc/zwaf476
Summarised from the published abstract; every number is checked against it