Coronary disease & ACSCohort study
Long-Term Prognosis of Coronary Aneurysms
- Ambispective international registry study
- consecutive patients
- multicentre (33 hospitals, 9 countries)
Authors' conclusion
The long-term prognosis of CAAs is not favorable, with MACEs associated with the underlying risk factor profile for atherosclerotic heart disease.
Study context
- Population
- Patients with coronary artery aneurysms (CAAs), 33 hospitals in 9 countries in America and Europe
- Participants
- 1,729 consecutive patients
- Outcome
- MACE:
- All-cause death
- HF
- Unstable angina
- Reinfarction
- Follow-up
- Median 44.8 months (Q1-Q3: 14.9-88.1)
Main finding
As reported in the abstract
MACE and predictors of MACE · median follow-up 44.8 months
- Major adverse cardiovascular event (MACE)
- 641 (37.1%)
- Death
- 379 (21.9%)
- Predictor: age
- HR 1.03; 1.02-1.04; P < 0.001 (95% CI)
- Predictor: DM
- HR 1.47; 1.23-1.75; P < 0.001 (95% CI)
- Predictor: renal insufficiency
- HR 1.53; 1.19-1.96; P = 0.010 (95% CI)
- Predictor: peripheral vessel disease
- HR 1.43; 1.13-1.82; P = 0.003 (95% CI)
- Predictor: reduced LVEF
- HR 0.98; 0.98-0.99; P < 0.001 (95% CI)
- Predictor: acute indication for index coronary angiography
- HR 1.30; 1.08-1.55; P = 0.005 (95% CI)
- Predictor: number of coronary vessels with severe stenosis
- HR 1.11; 1.02-1.20; P = 0.015 (95% CI)
Observational data: associations, not effects.
Further findings
Local aneurysm complications during follow-up
- Patients with local aneurysm complications
- 37
Original publication
Long-Term Prognosis of Coronary Aneurysms. JACC Cardiovasc Interv. Published 25 November 2024. doi:10.1016/j.jcin.2024.08.034
Summarised from the published abstract; every number is checked against it