Coronary disease & ACSCohort study
Long-term prognosis of unrecognized myocardial infarction in women and men from the general population: the Rotterdam Study
- Prospective cohort study
- population-based
Authors' conclusion
Unrecognized myocardial infarction has a differential impact on the long-term prognosis in women and men
Study context
- Population
- General population (Rotterdam Study), 57.6% women, mean age 64.8 years; baseline myocardial infarction (MI) status 1990–2008 by ECG and medical records
- Participants
- 12,303 participants
- Exposure
- Unrecognized myocardial infarction (UMI) or recognized MI (RMI) vs no MI
- UMIn = 512
- RMIn = 669
- No MIn = 11,122reference
- Outcome
- Heart failure (HF), atrial fibrillation (AF), stroke and all-cause mortality, by sex
Main finding
As reported in the abstract
HF, AF, stroke, all-cause mortality by sex
Each group vs no MIHazard ratio (95% CI)
UMIwomen, HF; lost significance after CV risk factor adjustment
1.31(1.01–1.71)
UMIwomen, all-cause mortality; lost significance after CV risk factor adjustment
1.21(1.05–1.40)
UMIwomen, stroke
1.27(0.95–1.70)
UMIwomen, AF
0.96(0.70–1.33)
RMIwomen, HF
2.58(1.94–3.43)
RMIwomen, AF
1.62(1.13–2.32)
RMIwomen, all-cause mortality
1.81(1.54–2.12)
RMIwomen, stroke
1.41(0.98–2.04)
UMImen, HF
1.90(1.45–2.48)
RMImen, HF
2.49(2.09–2.98)
UMImen, AF
1.91(1.45–2.54)
RMImen, AF
1.79(1.46–2.19)
UMImen, stroke
2.06(1.52–2.80)
RMImen, stroke
1.36(1.06–1.76)
UMImen, all-cause mortality
1.59(1.36–1.85)
RMImen, all-cause mortality
1.63(1.46–1.81)
Observational data: associations, not effects.
Original publication
Long-term prognosis of unrecognized myocardial infarction in women and men from the general population: the Rotterdam Study. Eur J Prev Cardiol. Published 27 October 2025. doi:10.1093/eurjpc/zwaf689
Summarised from the published abstract; every number is checked against it