Coronary disease & ACSSecondary analysis
Long-Term Prognostic Impact of Changes in Coronary Angiography–Derived Index of Microcirculatory Resistance Following Percutaneous Coronary Intervention (PCI)
- Secondary analysis of the FLAVOUR randomised trial
Authors' conclusion
An elevated Δangio-IMR correlates with a heightened risk of TVF in vessels with intermediate coronary stenosis underwent PCI.
Study context
- Population
- Vessels with intermediate coronary stenosis that underwent PCI, FLAVOUR trial
- Participants
- 814 vessels
- Comparison
- High vs low Δangio-IMR after PCI
- High Δangio-IMRn = 203
- Primary endpoint
- TVF (cardiac death, target vessel-related myocardial reinfarction, target vessel revascularization)
- Follow-up
- Long-term
Primary result
As reported in the abstract
TVF
High Δangio-IMR vs Low Δangio-IMRHazard ratio (95% CI)P value
TVF
1.82(1.15–2.88)
P = 0.011independent predictor
1.72(1.04–2.83)
P = 0.034Further findings
| Outcome | High Δangio-IMR | Low Δangio-IMR | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| TVF, by post-PCI angio-IMR (subgroup) · post-PCI angio-IMR >25 | 26.2% | 11.9% | 5.18 (1.28–20.94) | P = 0.021 | |
| TVF, by post-PCI angio-IMR (subgroup) · post-PCI angio-IMR ≤25 | 12.6% | 9.3% | 1.33 (0.77–2.29) | P = 0.305 | |
| 0.050.21520Hazard ratio (log scale) |
- Target vessel failure (TVF), by post-PCI angio-IMR (subgroup): interaction P = 0.028
Δangio-IMR
- Median Δangio-IMR (Q1-Q3: 0.50-5.00)
- 2.02
Original publication
Long-Term Prognostic Impact of Changes in Coronary Angiography–Derived Index of Microcirculatory Resistance Following PCI. JACC Cardiovasc Interv. Published 9 January 2026. doi:10.1016/j.jcin.2025.11.010
Summarised from the published abstract; every number is checked against it