Long-term prognostic role of persistent microvascular obstruction determined by cardiac magnetic resonance for ST-segment elevation myocardial infarction
Main finding · 5-year MACEResult — go to the resultOdds ratio 3.912 95% CI 1.904–8.037Authors' conclusion
Persistent MVO by CMR at the chronic phase of STEMI provides useful prognostic information regarding long-term outcomes after primary percutaneous coronary intervention.
Study context
- Population
- STEMI patients treated with primary PCI, with cardiac magnetic resonance (CMR) at 5–7 days and 6 months; mean age 57 years
- Participants
- 344 patients
- Exposure
- Persistent microvascular occlusion (MVO) vs transient MVO vs no MVO on CMR
- No MVOn = 192reference
- Transient MVOn = 105
- Persistent MVOn = 47
- Outcome
- MACE
- Follow-up
- 5 years
Methodological detailsmulticentre (6 centres in China), propensity-score matched (subanalysis)
- Multicentre (6 centres in China)
- Propensity-score matched (subanalysis)
Main finding
5-year MACE
Odds ratio
3.912
95% CI 1.904–8.037
P < 0.001
By group
Persistent MVO vs No MVO
OR 3.912 (95% CI 1.904–8.037); P < 0.001
As reported in the abstract
- Persistent MVO vs no MVO and transient MVO
- P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | No MVO | Transient MVO | Persistent MVO | P value | |
|---|---|---|---|---|---|
| MACE, propensity score-matched population (persistent vs transient MVO) | Not reported in the abstract | 37.2% | 65.1% | P = 0.010 | No MVO: not reported in the abstract |
- Major adverse cardiovascular events (MACE), propensity score-matched population (persistent vs transient MVO): matched 43 vs 43
Infarct size and LVEF at 5–7 days and 6 months
- Persistent MVO had the largest infarct size and the lowest LVEF
- all P < .001
Original publication
Long-term prognostic role of persistent microvascular obstruction determined by cardiac magnetic resonance for ST-segment elevation myocardial infarction. Am Heart J. Published 29 May 2025. doi:10.
Summarised from the published abstract; every number is checked against it