Coronary disease & ACSCohort study
Long-term prognostic value of stress cardiovascular magnetic resonance in patients with hypertension without known coronary artery disease
- Cohort study of consecutive patients referred for stress cardiovascular magnetic resonance (CMR)
- vasodilator stress CMR
Authors' conclusion
In patients with hypertension without known CAD, stress CMR is a long-term predictor for the incidence of MACE and offer an incremental prognostic value over traditional predictors.
Study context
- Population
- Patients with hypertension without known coronary artery disease (CAD) referred for stress CMR, December 2008 to January 202269 ± 12 years, 45% male, median follow up 6.7 (5.9–8.9) years
- Participants
- 2,019 patients
- Exposure
- Patients without ischaemia vs those with ischaemia on stress CMR
Main finding
As reported in the abstract
MACE:
- Cardiovascular mortality
- Non-fatal MI
Patients with major cardiovascular events (MACE)
327 (16%)
Observational data: associations, not effects.
Further findings
MACE by ischaemia
Association of ischaemia and unrecognized myocardial infarction (MI) with MACE
| Comparison | HR (99.5% CI) | P value | |
|---|---|---|---|
| Ischaemia | 4.1 (3.0–5.7) | P < 0.001 | |
| unrecognized MI | 3.6 (2.6–5.1) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Independent predictors of MACE after adjustment
| Comparison | HR (99.5% CI) | P value | |
|---|---|---|---|
| extent of ischaemia · adjusted | 1.2 (1.2–1.3) | P < 0.001 | |
| unrecognized MI · adjusted | 1.2 (1.1–1.3) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
- MACE by ischaemia: P < 0.001
Incremental value of stress CMR parameters (stepwise Model)
- C-statistic improvement
- 0.02
- net reclassification improvement
- 0.50
- integrative discrimination index
- 0.02
- all P < 0.001
Original publication
Long-term prognostic value of stress cardiovascular magnetic resonance in patients with hypertension without known coronary artery disease. Eur Heart J Cardiovasc Imaging. Published 23 June 2026. doi:10.1093/ehjci/jeag160
Summarised from the published abstract; every number is checked against it