Valvular & structural heart diseaseCohort study
Long-term risk of atrial fibrillation or flutter after transcatheter patent foramen ovale closure: a nationwide Danish study
- Nationwide cohort study
- matched 10:1 general population comparison cohort on age and sex
- multivariable-adjusted
Authors' conclusion
Patent foramen ovale closure was not associated with any substantial increased long-term risk of developing AF beyond the well-known procedure-related short-term risk.
Study context
- Population
- Danish nationwide cohorts with patent foramen ovale (PFO) closure, PFO diagnosis or matched general population, 2008–2020
- Participants
- 817 / 1,224 / 8,170
- Exposure
- PFO closure vs PFO diagnosis vs Matched
- PFO closuren = 817
- PFO diagnosisn = 1,224reference
- Matchedn = 8,170reference
- Outcome
- First-time AF (atrial fibrillation or flutter) diagnosis
Main finding
As reported in the abstract
AF
Hazard ratio (95% CI)
PFO closure vs PFO diagnosiswithin the first 3 months
2.3(1.3–4.0)
PFO closure vs PFO diagnosisafter 3 months
0.7(0.3–1.7)
PFO closure vs Matchedwithin the first 3 months
51(21–125)
PFO closure vs Matchedafter 3 months
2.5(1.2–5.0)
Observational data: associations, not effects.
Original publication
Long-term risk of atrial fibrillation or flutter after transcatheter patent foramen ovale closure: a nationwide Danish study. Eur Heart J. Published 3 June 2023. doi:10.1093/eurheartj/ehad305
Summarised from the published abstract; every number is checked against it