Valvular & structural heart disease
Long-term structural valve deterioration after transcatheter aortic valve implantation (TAVI): insights from the EORP ESC Valve Durability TAVI Registry
Authors' conclusion
The incidence of moderate/severe SVD during long-term follow-up after TAVI is low, with severe SVD being even rarer than moderate SVD. SVD occurs more frequently in patients treated with older-generation intra-annular valves and in those with small-sized THVs.
Study context
- Population
- Consecutive living patients who underwent TAVI up until 2014 using any commercially available transcatheter heart valveaged 79.6±7.1 years at the time of TAVI, 47.2% male, mean Society of Thoracic Surgeons score 5.0%
- Participants
- 597 participants
- Outcome
- Crude incidence of moderate/severe SVD
- Follow-up
- Median of 6.1 years (interquartile range 5.2-7.3 years)
Methodological details22 participant centres, 61% evaluated independently by a central core laboratory
- 22 participant centres
- 61% evaluated independently by a central core laboratory
Main finding
As reported in the abstract
Moderate/severe structural valve deterioration (SVD)
9.5%
n=57
Moderate
6.2%, n=37
Severe
3.4%, n=20
Observational data: associations, not effects.
Further findings
Predictors of SVD (Cox regression)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Use of an intra-annular THV | 38.44 (10.8–136.3) | P < 0.001 | |
| A small THV size | 4.82 (2.42–9.60) | P < 0.001 | |
| Moderate/severe postprocedural paravalvular leak | 3.64 (1.59–8.32) | P = 0.002 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Long-term structural valve deterioration after TAVI: insights from the EORP ESC Valve Durability TAVI Registry. EuroIntervention. Published 16 May 2025. doi:10.
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