Long-term Trends in Upper Gastrointestinal Bleeding and Ischemic Outcomes after Myocardial Infarction
Authors' conclusion
Bleeding hospitalizations after MI increased until 2013-14, with UGIB the most common source, while ischemic outcomes declined. These opposing trends were associated with the adoption of invasive management and intensified antithrombotic therapy.
Study context
- Population
- Patients with acute myocardial infarction (MI) in the SWEDEHEART registry discharged alive on antithrombotic treatment, 1999–2020
- Outcome
- Trends of UGIB hospitalization in relation to other bleeding and ischemic outcomes
- Follow-up
- One year
Methodological detailsSWEDEHEART registry, trends in 2-year intervals, standardized event rates
- SWEDEHEART registry
- Trends in 2-year intervals
- Standardized event rates
Main finding
As reported in the abstract
Bleeding hospitalizations increased
2.4% to 4.5%
Bleeding hospitalizations peak in 2013-14
4.7%
One-year MACCE decreased
20.1% to 9.4%
Observational data: associations, not effects.
Further findings
- PCI, DAPT, potent antiplatelet agents and DOACs increased over time
- Standardized event rates for upper gastrointestinal bleeding (UGIB) suggest changes in incidence were associated with evolving management strategies
Original publication
Long-term Trends in Upper Gastrointestinal Bleeding and Ischemic Outcomes after Myocardial Infarction. Eur J Prev Cardiol. Published 26 September 2026. doi:10.
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