Cardio-oncology & otherCohort study
Longitudinal [ 18 F]FDG PET/MR Assessment of Arterial Inflammation in Patients With Prostate Cancer Undergoing Androgen Deprivation Therapy
- longitudinal [ 1 8 F]fluorodeoxyglucose positron emission tomography/magnetic resonance examinations
- paired tests
- linear mixed-effects models
Authors' conclusion
In patients with prostate cancer, ADT is associated with consistent and progressive arterial inflammation, most prominently in carotid, iliac, and abdominal aortic regions. These findings support arterial inflammation as a potential imaging phenotype of ADT-associated cardiovascular risk.
Study context
- Population
- Men with prostate cancer undergoing androgen deprivation therapy (ADT)men with prostate cancer, 2 longitudinal examinations each
- Participants
- Forty-three men
- Exposure
- Intraindividual change in arterial TBR max across ADT exposure
Main finding
As reported in the abstract
TBR max, carotid arteries
Change across ADT exposure
1.54±0.32 to 1.75±0.31
Observational data: associations, not effects.
Further findings
TBR max, abdominal aorta
- Change across ADT exposure
- 1.89±0.39 to 2.19±0.36
- P <0.001
TBR max, common iliac arteries
- Change across ADT exposure
- 1.88±0.45 to 2.24±0.54
- P <0.001
TBR max, aortic arch
- Significant increase
- P =0.005
TBR max, ascending aorta
- Significant increase
- P =0.02
All-artery, aorta, and branch composite TBR max
- Increased significantly
- all P <0.001
Monthly increment in TBR max (linear mixed-effects models)
- iliac arteries
- 0.0205/mo
- carotid arteries
- 0.0123/mo
- abdominal aorta
- 0.0098/mo
- iliac P <0.001
- carotid P <0.001
- abdominal aorta P =0.038
Original publication
Longitudinal [ 18 F]FDG PET/MR Assessment of Arterial Inflammation in Patients With Prostate Cancer Undergoing Androgen Deprivation Therapy. Circ Cardiovasc Imaging. Published 28 July 2026. doi:10.1161/circimaging.126.019636
Summarised from the published abstract; every number is checked against it