Heart failure & cardiomyopathiesCohort study
Longitudinal Changes in Left Ventricular Diastolic Function in Late Life
- Prospective cohort study
- community-based
Authors' conclusion
Diastolic function generally deteriorates over 6.6 years in late life, particularly among persons with CV risk factors, and is associated with development of dyspnea.
Study context
- Population
- Older adults in the ARIC study with echocardiography at visits 5 (2011–2013) and 7 (2018–2019)
- Participants
- 2,524 adults
- Outcome
- Intraindividual change in diastolic measures: tissue Doppler e', E/e' ratio and LAVI
- Follow-up
- Over 6 years
Main finding
As reported in the abstract
mean 6.6 ± 0.8 years
Change in e'septal (decrease)
0.6 ± 1.4 cm/s
Change in E/e'septal (increase)
3.1 ± 4.4
Change in left atrial volume index (LAVI) (increase)
2.3 ± 6.4 mL/m²
Proportion with ≥2 abnormal diastolic measures, visit 5 to visit 7
17% to 42% (P < 0.001)
Observational data: associations, not effects.
Further findings
Change in E/e'septal and LAVI by cardiovascular (CV) risk status
- Greater increases in E/e'septal and LAVI with prevalent CV risk factors or diseases but no prevalent or incident heart failure (HF) (n = 2,150) vs free of CV risk factors or diseases (n = 234)
Dyspnea development between visits
- Increases of E/e'septal and LAVI both associated with development of dyspnea
- adjusted for CV risk factors
Original publication
Longitudinal Changes in Left Ventricular Diastolic Function in Late Life. JACC Cardiovasc Imaging. Published 10 May 2023. doi:10.1016/j.jcmg.2023.02.022
Summarised from the published abstract; every number is checked against it