Cardio-oncology & otherCohort study
Longitudinal Patterns of Cardiovascular Disease and Cancer Mortality in Renal Cell Carcinoma Patients by Tumor Stage
- Retrospective cohort study
- SEER database
- competing risk analysis
Authors' conclusion
In RCC patients, stage I individuals showed a pronounced trend where CVD death became dominant over RCC death during survivorship, with consistent patterns by different sociodemographic and clinical characteristics.
Study context
- Population
- Adults with a first renal cell carcinoma (RCC), SEER database 2004–2020
- Participants
- 116,836 adults
- Outcome
- Crossover time when CVD death rate overtakes RCC death rate
- Follow-up
- 16-year follow-up
Main finding
As reported in the abstract
Crossover time (CVD death rate overtakes RCC death rate)
Overall crossover time, years
13.7 (95% CI 12.0-15.4)
Stage I crossover time, years
2.8 (95% CI 2.0-3.7)
Observational data: associations, not effects.
Further findings
Crossover by subgroup
- Stage I: all subgroups had a crossover or consistently higher cardiovascular disease (CVD) than RCC death rate
- Age ≥75 years and non-Hispanic Black patients had a crossover across all tumor stages
Original publication
Longitudinal Patterns of Cardiovascular Disease and Cancer Mortality in Renal Cell Carcinoma Patients by Tumor Stage. JACC CardioOncol. doi:10.1016/j.jaccao.2025.06.004
Summarised from the published abstract; every number is checked against it