Loss of the Coronary Artery Disease Risk Gene LMOD1 in Vascular Smooth Muscle Cells Triggers Rapid-Onset Coronary Atherosclerosis
Authors' conclusion
Under atherogenic conditions, Lmod1SMKO mice present with rapid-onset coronary atherosclerosis. LMOD1 safeguards coronary homeostasis, apparently in an actin nucleation-independent manner.
Study context
- Population
- Mice subjected to atherogenic regimens; mouse and human coronary arteries
- Comparison
- Vascular smooth muscle cell (VSMC)-restricted Lmod1 knockout vs control mice
- Outcome
- Coronary atherosclerosis under atherogenic conditions
Methodological detailsmouse model, VSMC-restricted knockout
- Mouse model
- VSMC-restricted knockout
Main finding
As reported in the abstract
Coronary plaque cells of VSMC origin (immunogold lineage tracing)
46%
Original publication
Loss of the Coronary Artery Disease Risk Gene LMOD1 in Vascular Smooth Muscle Cells Triggers Rapid-Onset Coronary Atherosclerosis. Circulation. Published 4 August 2026. doi:10.
Summarised from the published abstract; every number is checked against it