Prevention & lipidsCohort study
Low-density lipoprotein cholesterol, coronary plaque burden, and myocardial infarction in adults aged 76–92 years: the Western Denmark Heart Registry
- Cohort study
- registry-based
Authors' conclusion
In statin-naïve symptomatic individuals aged 76-92, higher LDL-C was associated with CAC >90th percentile, post-CCTA revascularization, and increased risk of MI.
Study context
- Population
- Symptomatic statin-naïve individuals undergoing coronary computed tomography angiography (CCTA), Western Denmark Heart Registry, 2008–20211,562 aged 76–92
- Participants
- 37,910 individuals
- Exposure
- Low-density lipoprotein cholesterol (LDL-C) per 1 mmol/L higher, by age group
- Age 76-92n = 1,562
- Outcome
- CAC >90th percentile (aRR); post-CCTA revascularization within 90 days (aRR); MI (aHR)
Main finding
As reported in the abstract
Per 1 mmol/L higher LDL-C
| Group | Adjusted risk ratio (aRR) CAC >90th percentile | aRR post-CCTA revascularization | aHR myocardial infarctions (MI) |
|---|---|---|---|
| Age 76-92 | 1.19 (95% CI: 1.00-1.40) | 1.41 (1.22-1.64) | 1.57 (1.06-2.32) |
| Age 61-75 | 1.07 (1.01-1.14) | 1.32 (1.23-1.41) | 1.22 (1.03-1.44) |
Observational data: associations, not effects.
Original publication
Low-density lipoprotein cholesterol, coronary plaque burden, and myocardial infarction in adults aged 76–92 years: the Western Denmark Heart Registry. Eur J Prev Cardiol. Published 16 February 2026. doi:10.1093/eurjpc/zwag108
Summarised from the published abstract; every number is checked against it