Coronary disease & ACSSecondary analysis
Low-Density Lipoprotein Cholesterol Levels and Neoatherosclerosis After STEMI
- Secondary analysis of the CONNECT randomised trial
- post hoc analysis
- 7 sites in Switzerland and Japan
Authors' conclusion
On-treatment LDL-C level emerged as an independent predictor of neoatherosclerosis 3 years after DES implantation for STEMI. Neoatherosclerosis was less frequent among patients who achieved the guideline-recommended on-treatment LDL-C level
Study context
- Population
- Patients with STEMI treated with primary percutaneous coronary intervention (PCI) with everolimus-eluting drug-eluting stent (DES), who underwent optical coherence tomography (OCT) at 3 yearsunderwent OCT at 3 years
- Participants
- 178 patients
- Comparison
- Target low-density lipoprotein cholesterol (LDL-C) achieved vs not achieved
- Target LDL-C achievedn = 98reference
- Target LDL-C not achievedn = 80
- Primary endpoint
- Prevalence of neoatherosclerosis on OCT
- Follow-up
- 3 years after primary PCI
Primary result
Neoatherosclerosis · 3 years
Odds ratio
3.00
95% CI 1.19–8.24
P = 0.02
Events by treatment group
Target LDL-C not achieved vs Target LDL-C achieved
OR 3.00 (95% CI 1.19–8.24); P = 0.02
As reported in the abstract
Further findings
On-treatment LDL-C
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Neoatherosclerosis per 25-mg/dL increase in on-treatment LDL-C (multivariable) · 3 years · multivariable logistic regression | 1.46 (1.09–2.01) | P = 0.01 | |
| 0.512Odds ratio (log scale) |
Original publication
Low-Density Lipoprotein Cholesterol Levels and Neoatherosclerosis After STEMI. JAMA Cardiol. Published 1 February 2026. doi:10.1001/jamacardio.2025.4723
Summarised from the published abstract; every number is checked against it