Low-grade inflammation and cardiovascular events among patients with chronic kidney disease
Main finding · MACE (composite of stroke, myocardial infarction, or cardiovascular death)Result — go to the resultCause-specific hazard 12% 95% CI 0–26Authors' conclusion
In CKD patients not yet on kidney replacement therapy, systemic low-grade inflammation, measured through hs-CRP, is associated with occurrence of cardiovascular events independently of traditional risk factors, including a history of ASCVD.
Study context
- Population
- Adults with chronic kidney disease (CKD) stages 2–5 not yet on kidney replacement therapypatients included
- Participants
- 2,078 adults
- Exposure
- Twofold increase in baseline hs-CRP
- Outcome
- MACE:
- Stroke
- Myocardial infarction
- Cardiovascular death
- Follow-up
- Median 5 years
Methodological details40 French nephrology outpatient facilities
- 40 French nephrology outpatient facilities
Main finding
As reported in the abstract
Cause-specific hazard
12%
95% CI 0–26
Twofold increase in hs-CRP
cause-specific hazard 12% (95% CI 0–26)
- Patients had a major adverse cardiovascular events (MACE)
- 171
Observational data: associations, not effects.
Further findings
Hospitalization for heart failure (HHF) · median follow-up of 5 years
| Comparison | Cause-specific hazard (95% CI) | |
|---|---|---|
| Twofold increase in hs-CRPHigher; after controlling for potential confounders · after controlling for potential confounders | 26% (13–40) | |
| −200204060Change in hazard, % (linear scale) |
- Hospitalization for heart failure (HHF) — patients had HHF
- 207
Baseline characteristics
- Men
- 67%
- Mean (SD) age
- 67(13) years
- Mean eGFR
- 36(12) mL/min/1.73 m²
- History of atherosclerotic cardiovascular disease (ASCVD)
- 38%
- Median hs-CRP concentration (inter-quartile range)
- 2.4 mg/L (1.1-5.1)
Original publication
Low-grade inflammation and cardiovascular events among patients with chronic kidney disease. Eur J Prev Cardiol. Published 22 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it