Cardiometabolic & kidneyCohort study
Low-grade inflammation predicts major cardiovascular events and mortality in recently diagnosed type 2 diabetes: a Danish nationwide cohort study
- Prospective cohort study
- nationwide
Authors' conclusion
Low-grade inflammation was associated with MACE and all-cause mortality, independently of classical risk factors, in individuals recently diagnosed with type 2 diabetes and without prevalent CVD. Despite improved predictive ability of IL-6 and hsCRP, the absolute improvement was sparse.
Study context
- Population
- Individuals recently diagnosed with T2DM (median duration 0.9 years) without prevalent CVD, Denmarkprevalent CVD (n=1390) excluded
- Participants
- 7,630 participants
- Exposure
- Per 1-SD increase in log-IL-6, log-TNF-α and log-hsCRP
Main finding
As reported in the abstract
MACE and all-cause mortality per 1-SD increase in log-biomarker · median follow-up 9 years
Hazard ratio (95% CI)
log-IL-6 (1-SD, 1.98 pg/mL)MACE
1.16(1.09–1.23)
log-TNF-α (1-SD, 1.40 pg/mL)MACE
1.01(0.95–1.08)
log-hsCRP (1-SD, 3.28 mg/L)MACE
1.16(1.09–1.25)
log-IL-6 (1-SD, 1.98 pg/mL)all-cause mortality
1.38(1.31–1.45)
log-TNF-α (1-SD, 1.40 pg/mL)all-cause mortality
1.16(1.10–1.22)
log-hsCRP (1-SD, 3.28 mg/L)all-cause mortality
1.34(1.25–1.43)
Per 1-SD increase in log-biomarker, as printed
Observational data: associations, not effects.
Further findings
Prediction of major adverse cardiac event (MACE) and all-cause mortality
- Prediction slightly improved by adding IL-6 and high-sensitivity C-reactive protein (hsCRP) to classical risk factor model
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Low-grade inflammation predicts major cardiovascular events and mortality in recently diagnosed type 2 diabetes: a Danish nationwide cohort study. Eur J Prev Cardiol. Published 16 September 2026. doi:10.1093/eurjpc/zwag495
Summarised from the published abstract; every number is checked against it