Arrhythmias & electrophysiologyRandomised controlled trial
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial
- Randomised controlled trial
- multicentre
Authors' conclusion
In conclusion, LVA ablation in addition to PVI did not significantly reduce 1-year AF or AT recurrence in patients with persistent AF with left atrial LVAs.
Study context
- Population
- Patients with persistent atrial fibrillation (AF) and left atrial low-voltage areas ≥5 cm² on voltage map after pulmonary vein isolation (PVI)SUPPRESS-AF
- Participants
- 170 vs 171
- Comparison
- PVI + LVA ablation vs PVI alone
- PVI + LVA-ABLn = 170
- PVI-alonen = 171reference
- Primary endpoint
- Freedom from AF or AT recurrence without antiarrhythmic drug use
- Follow-up
- 1 year
Primary result
As reported in the abstract
P for log(rank) test = 0.127
Safety
Procedure-related serious adverse events
- Procedure-related serious adverse events — No difference between the two groups
- P < 0.0001
Original publication
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial. Nat Med. Published 30 April 2025. doi:10.1038/s41591-025-03674-y
Summarised from the published abstract; every number is checked against it