Cohort study
Lower extremity arterial disease vs. coronary artery disease: mortality differences after revascularization
- Retrospective cohort study
Authors' conclusion
Mortality risk was almost three-fold higher in patients undergoing revascularization for LEAD than in those with CAD. The excessive mortality was considerably attributable to inter-group differences in baseline characteristics, including potentially clinically or socially modifiable factors.
Study context
- Population
- Patients undergoing revascularization for coronary artery disease (CAD) or lower extremity arterial disease
- Participants
- 10,754 patients
- Exposure
- Revascularization for lower extremity arterial disease (LEAD) vs CAD
- LEADn = 4,405
- CADn = 6,349reference
- Outcome
- Mortality
- Follow-up
- 1 year
Main finding
As reported in the abstract
Mortality incidence
LEAD vs CADEstimate (95% CI)
Mortality incidence
crude risk ratio 2.91(2.54–3.34)
adjusted for age, sex, polyvascular disease; attenuation 29%
incidence risk ratio 2.14(1.83–2.50)
+ comorbidities; attenuation 64%
incidence risk ratio 1.48(1.26–1.72)
+ medications; attenuation 73%
incidence risk ratio 1.33(1.12–1.58)
+ vulnerabilities; attenuation 86%
incidence risk ratio 1.17(0.98–1.39)
Observational data: associations, not effects.
Further findings
Baseline characteristics
- LEAD older, more polyvascular disease and comorbidities, fewer cardioprotective drugs; vulnerabilities more common after adjustment
Original publication
Lower extremity arterial disease vs. coronary artery disease: mortality differences after revascularization. Eur Heart J. Published 2 May 2024. doi:10.1093/eurheartj/ehae207
Summarised from the published abstract; every number is checked against it