LPA Gene, Ethnicity, and Cardiovascular Events
Authors' conclusion
The prevalence and association of LPA SNPs with size of apolipoprotein(a) isoforms, Lp(a), and OxPL-apoB levels are highly variable and ethnicity-specific. The relationship to MACE is best explained by elevated plasma Lp(a) or OxPL-apoB levels, despite significant ethnic differences in LPA genetic markers.
Study context
- Population
- Black, white and Hispanic subjects enrolled in the Dallas Heart Study1,792 black, 1030 white, 597 Hispanic
- Exposure
- Quartile 4 vs Quartile 1
- Outcome
- Time to MACE
- Follow-up
- median 9.5-year follow-up
Main finding
As reported in the abstract
Time to MACE, entire cohort (multivariable Cox)
Quartile 4 vs Quartile 1Hazard ratio (95% CI)P value
Lp(a)
2.35(1.50–3.69)
P < 0.001OxPL-apoB
1.89(1.26–2.84)
P = 0.003Observational data: associations, not effects.
Further findings
Prevalence of LPA single nucleotide polymorphisms (SNPs) by ethnicity
- rs3798220 most prevalent in Hispanics
- 42.38%
- rs10455872 most prevalent in whites
- 14.27%
- rs9457951 most prevalent in blacks
- 32.92%
- Correlation of each SNP with major apo(a) isoform size highly variable and in different directions among ethnic groups
Predictors of time to major adverse cardiovascular events (MACE) by ethnic group
- Blacks: Lp(a) positive predictor; major apo(a) isoform size inverse predictor
- Whites: major apo(a) isoform size inverse predictor
- Hispanics: OxPL-apoB positive predictor
Original publication
LPA Gene, Ethnicity, and Cardiovascular Events. Circulation. Published 9 November 2016. doi:10.
Summarised from the published abstract; every number is checked against it