Pulmonary vascular disease & thromboembolism
LRP5, a WNT signalling pathway receptor, and platelet activation
Authors' conclusion
These findings reveal for the first time that LRP5 plays a critical role in platelet adhesion and thrombus formation.
Study context
- Population
- Human platelets and platelets from wild-type and Lrp5-deficient mice
- Comparison
- Lrp5-/- vs wild-type mice; LRP5 inhibition of human platelets
Methodological detailspreclinical, human platelets and Lrp5-deficient mice
- Preclinical
- Human platelets and Lrp5-deficient mice
Main finding
As reported in the abstract
- Platelet aggregation (LTA) and flow-dependent deposition on collagen significantly lower in Lrp5-/- than wild-type (Wt)
- In vivo carotid artery occlusion time significantly prolonged in Lrp5-/- mice
- GPVI signalling intact; reduced α- and dense granule release after ADP and reduced membrane purinergic receptors in Lrp5-/- platelets
- VASP phosphorylation: P2Y12 downstream signalling dysfunctional in LRP5-deficient platelets
- Human platelets express high LRP5; flow-mediated deposition and LTA highly reduced by LRP5 inhibition
Safety
- LRP5 deletion did not significantly affect coagulation nor induce bleeding
- Under the experimental conditions tested
Original publication
LRP5, a WNT signalling pathway receptor, and platelet activation. Eur Heart J. Published 3 October 2025. doi:10.
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