Heart failure & cardiomyopathies
Lymphocyte-to-C-Reactive Protein Ratio and Score in Patients with Heart Failure: Nutritional Status, Physical Function, and Prognosis
Authors' conclusion
LCR and LCS emerge as potential predictors of nutritional status, physical function, and prognosis in older patients with HF.
Study context
- Population
- Patients hospitalised with heart failure (HF) (mean age 80.2 ± 7.8 years; 513 women)
- Participants
- 1,212 patients
- Comparison
- LCS score 0 vs 1 vs 2
- LCS 0n = 498reference
- LCS 1n = 533
- LCS 2n = 181
- Primary endpoint
- All-cause death
- Follow-up
- 2 years
Methodological detailsmulticentre, 15 hospitals in Japan
- Multicentre
- 15 hospitals in Japan
Primary result
As reported in the abstract
Hazard ratio (95% CI)P value
LCS 2vs LCS 0
1.64(1.14–2.35)
P = 0.007Log-transformed LCR
0.88(0.81–0.95)
P = 0.002- Difference across LCS groups
- P = 0.001
Further findings
| Outcome | Continuous net reclassification improvement (95% CI) | P value |
|---|---|---|
| Additional prognostic predictability of LCR vs conventional risk model | 0.153 (0.007–0.299) | P = 0.041 |
Nutritional status and physical function
- Lower LCR and higher LCS independently associated with worse nutritional status, lower handgrip strength, shorter physical performance battery score and shorter 6-min walk distance (multivariate linear regression)
Original publication
Lymphocyte-to-C-Reactive Protein Ratio and Score in Patients with Heart Failure: Nutritional Status, Physical Function, and Prognosis. ESC Heart Fail. Published 10 July 2024. doi:10.
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