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Heart failure & cardiomyopathiesCohort study

Magnetic Resonance Imaging Characterization and Clinical Outcomes of Dilated and Arrhythmogenic Left Ventricular Cardiomyopathies

J Am Coll CardiolPublished

  • Retrospective cohort study
  • multicentre
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Authors' conclusion

In a multicenter cohort of patients with DCM and NDLVC, septal LGE together with LV dilatation, age, advanced disease, and frequent and repetitive ventricular arrhythmias were powerful predictors of major arrhythmic events.

Study context

Population
Patients with dilated cardiomyopathy (DCM) or nondilated left ventricular cardiomyopathy (NDLVC) with cardiac magnetic resonance (CMR) data from 4 referral centres
Participants
462 patients · 4 referral centres
Exposure
NDLVC vs DCM
  • NDLVCn = 235
  • DCMn = 227reference
Outcome
Composite of:
  • SCD
  • Major ventricular arrhythmias
Follow-up
Median 81 months (Q1-Q3: 40-132 months)

Main finding

SCD or major ventricular arrhythmias · median follow-up 81 months

Hazard ratio

1.929

95% CI 1.033–3.601

P = 0.039

Septal LGE vs DCM
HR 1.929 (95% CI 1.033–3.601); P = 0.039

As reported in the abstract

Study outcome occurred, all patients
98 (21%)

Observational data: associations, not effects.

Further findings

P/LP variants of arrhythmogenic genes

P < 0.001

Free-wall LGE

P < 0.001

P/LP variants of nonarrhythmogenic genes

P = 0.002

Septal LGE

P = 0.004

OutcomeDCMNDLVCP value
LVEF36% ± 15%51% ± 12%P < 0.001

Original publication

Magnetic Resonance Imaging Characterization and Clinical Outcomes of Dilated and Arrhythmogenic Left Ventricular Cardiomyopathies. J Am Coll Cardiol. Published 14 May 2024. doi:10.1016/j.jacc.2024.02.041
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Summarised from the published abstract; every number is checked against it