Arrhythmias & electrophysiologyCohort study
MAGNETOcardiography Parameters to Predict Sudden Cardiac Death (MAGNETO-SCD) or Ventricular Events From Implantable Cardioverter Defibrillators
- prospective, multicenter observational study
- 5 UK hospitals
- portable, unshielded, room temperature device
Authors' conclusion
In the current study, novel rotation-based MCG parameters were associated with subsequent appropriate ICD therapies, particularly shocks. These exploratory findings support the feasibility of unshielded MCG in routine clinical practice and suggest that Rotation Score/Angular Dynamics may capture arrhythmic substrate and merit further investigation and validation in larger cohorts. (Magnetocardiography [MCG] Parameters in the Prediction of Future ICD Therapy [Magneto-SCD]; NCT04352816; EudraCT2019-002994-78).
Study context
- Population
- De novo implantable-cardioverter defibrillator (ICD) recipients, September 2019 to November 2021patients recruited, 90 had analyzable magnetocardiography (MCG) data
- Participants
- 104 recipients
- Exposure
- MCG parameters (Rotation Score and Angular Dynamics) in patients with vs without subsequent appropriate ICD therapy
- appropriate ICD therapyn = 17
- Outcome
- Occurrence of any appropriate ICD therapy
- Follow-up
- Mean 36.0 ± 17.5 months
Main finding
As reported in the abstract
Rotation Score, median (Q1-Q3), appropriate ICD therapy vs not
504.4 [398.5-665.3] vs 331.7 [256.6-472.2]; P = 0.005
Angular Dynamics, median (Q1-Q3), appropriate ICD therapy vs not
3.26 [2.55-3.81] vs 2.50 [2.12-3.13]; P = 0.029
Observational data: associations, not effects.
Secondary outcomes
| Outcome | hazard (95% CI) |
|---|---|
| Appropriate shocks — Each 1-SD increase in Rotation Score · higher hazard of appropriate shocks · CIs were wide and event numbers were small | 2.53 (1.53–4.18) |
| Appropriate shocks — Each 1-SD increase in Angular Dynamics · higher hazard of appropriate shocks · CIs were wide and event numbers were small | 2.34 (1.37–4.00) |
- Appropriate shocks — Rotation Score, with appropriate shocks vs not
- 539.7 [428.5-674.5] vs 335.1 [256.3-476.6]; P = 0.001
- Appropriate shocks — Angular Dynamics, with appropriate shocks vs not
- 3.348 [2.879-3.830] vs 2.492 [2.117-3.132]; P = 0.005
- Appropriate shocks — Receiver-operating characteristic area under the curve for shocks, Rotation Score
- 0.82
- Appropriate shocks — Receiver-operating characteristic area under the curve for shocks, Angular Dynamics
- 0.77
- Appropriate shocks: Associations persisted after limited adjustment for age and left ventricular ejection fraction; requires independent validation
Original publication
Summarised from the published abstract; every number is checked against it