Cohort study
Major cardiovascular events and subsequent risk of kidney failure with replacement therapy: a chronic kidney disease (CKD) Prognosis Consortium study
- Cohort study (consortium meta-analysis)
- time-varying exposures
Authors' conclusion
Incident CVD events strongly and independently associate with future KFRT risk, most notably after HF, then CHD, stroke, and AF.
Study context
- Population
- Individuals in the CKD Prognosis Consortium with known baseline estimated glomerular filtration rate (eGFR)CKD Prognosis Consortium
- Participants
- 25,903,761 individuals
- Exposure
- Incident cardiovascular disease (CVD) events vs none
- Outcome
- Kidney failure with replacement therapy (KFRT)
Main finding
As reported in the abstract
KFRT
Adjusted hazard ratio (95% CI)
Incident CHD
3.1(2.9–3.3)
Incident stroke
2.0(1.9–2.1)
Incident HF
4.5(4.2–4.9)
Incident AF
2.8(2.7–3.1)
- Kidney failure with replacement therapy (KFRT) during follow-up
- 101 044 (0.4%)
Observational data: associations, not effects.
Further findings
KFRT within 3 months of incident heart failure (HF) hospitalization
| Comparison | HR (95% CI) | |
|---|---|---|
| Incident HF · adjusted for other CVD subtype incidence | 46 (43–50) | |
| 0.050.21520Hazard ratio (log scale) |
Time course of KFRT risk after CVD
- Hazard ratios (HRs) highest in first 3 months post-CVD, declining to baseline after 3 years
Original publication
Major cardiovascular events and subsequent risk of kidney failure with replacement therapy: a CKD Prognosis Consortium study. Eur Heart J. Published 24 January 2023. doi:10.1093/eurheartj/ehac825
Summarised from the published abstract; every number is checked against it