Prevention & lipidsCohort study
Major cardiovascular events in first-degree relatives of individuals with elevated plasma lipoprotein(a): a registry-based cohort study
- Registry-based cohort study
Authors' conclusion
First-degree relatives of individuals with elevated Lp(a) levels have a higher incidence of MACE.
Study context
- Population
- First-degree relatives aged 35–69 years without a measured Lp(a), of indexes with a routine plasma Lp(a) measurement, Swedish STRIREG cohort41,304 indexes
- Participants
- 61,715 relatives
- Exposure
- First-degree relatives (FDRs) by index Lp percentile stratum
- Outcome
- MACE:
- CV death
- MI
- Ischaemic stroke
- Coronary revascularization
- Follow-up
- Median 19 (11-26) years
Main finding
As reported in the abstract
MACE in FDRs by index Lp(a) percentile stratum · median follow-up 19 (11-26) years; cumulative incidence until age 65
| Group | Value | HR for major adverse cardiovascular events (MACE) | HR for MACE vs lowest stratum (95% CI) |
|---|---|---|---|
| <50th | 6.2% | reference (lowest stratum) | |
| ≥95th | 8.1% | 1.28 (1.06-1.55) |
- FDRs with a MACE
- 2043
Observational data: associations, not effects.
Further findings
Lp(a) concordance among related indexes (nested analysis, n = 4243)
- Concordance, <80th percentile
- 86%
- Concordance, ≥80th percentile
- 53%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Major cardiovascular events in first-degree relatives of individuals with elevated plasma lipoprotein(a): a registry-based cohort study. Eur Heart J. Published 31 August 2025. doi:10.1093/eurheartj/ehaf677
Summarised from the published abstract; every number is checked against it