Heart failure & cardiomyopathies
Malignant left ventricular hypertrophy and risk of cognitive impairment in SPRINT MIND trial
Authors' conclusion
Among SPRINT participants, malignant LVH is associated with incident probable dementia and mild cognitive impairment.
Study context
- Population
- SPRINT MIND participants with ≥1 follow-up cognitive assessment (mean age 67.9 ± 9.3 years), classified into 6 left ventricular hypertrophy (LVH)/biomarker groups
- Participants
- 8,027 participants
- Comparison
- Concomitant LVH and elevated hs-cTnT and NT-proBNP (malignant LVH) vs no LVH with normal biomarkers
- Primary endpoint
- Incident probable dementia, MCI and composite of MCI/probable dementia
- Follow-up
- Median 5 years
Primary result
As reported in the abstract
Probable dementia, MCI, composite MCI/probable dementia
LVH + both biomarkers elevated vs No LVH, normal biomarkersHazard ratio (95% CI)
Probable dementia
2.50(1.26–4.95)
MCI
1.78(0.99–3.23)
Composite MCI/probable dementia
1.89(1.16–3.10)
- Incident mild cognitive impairment (MCI) events (overall)
- 306
- Incident probable dementia events (overall)
- 597
- Incident composite MCI/probable dementia events (overall)
- 818
Original publication
Malignant left ventricular hypertrophy and risk of cognitive impairment in SPRINT MIND trial. Am Heart J. Published 25 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →