Cardio-oncology & otherCohort study
Management and Outcomes of Cardiac Sarcoidosis: Insights From the Nationwide MYSTICS Registry
- multicenter retrospective registry
- nationwide
- consecutive patients
Authors' conclusion
This large-scale multicenter registry showed that clinical presentation and prognosis differ depending on the presence or absence of extracardiac lesions and histological evidence; therefore, it is necessary to recognize the characteristics of each phenotype in managing CS.
Study context
- Population
- Patients with cardiac sarcoidosis (CS) newly diagnosed between 2012 and 2021newly diagnosed between 2012 and 2021, analyzed of 2366 enrolled
- Participants
- 1,852 patients
- Exposure
- 4 groups stratified based on diagnostic criteria: definite CS, probable CS, presumed systemic sarcoidosis, and presumed isolated CS
- Outcome
- composite of:
- All-cause death
- Heart failure hospitalization
- Fatal ventricular arrhythmic event
- Follow-up
- median 5.1-year follow-up
Main finding
As reported in the abstract
primary outcome occurred in 519 patients
28%, 6.4/100 patient-years
Observational data: associations, not effects.
Secondary outcomes
Recurrence and subsequent primary end point
| Comparison | hazard ratio (95% CI) | P value | |
|---|---|---|---|
| Recurrence · recurrence associated with subsequent primary end point | 1.38 (1.00–1.89) | P = 0.048 | |
| 0.512Hazard ratio (log scale) |
Cardiac imaging performance rates
- cardiac magnetic resonance
- 64%
- 18 F-fluorodeoxyglucose positron emission tomography
- 82%
- diagnosed clinically without histological evidence
- 974 (53%)
Immunosuppressive therapy
- received immunosuppressive therapy
- 89%
recurrence of CS (secondary end point)
- developed recurrence during steroid tapering
- 291 (18%, 4.1/100 patient-years)
- 5-year recurrence rate
- 17.0%
Original publication
Management and Outcomes of Cardiac Sarcoidosis: Insights From the Nationwide MYSTICS Registry. Circ Heart Fail. Published 10 September 2026. doi:10.1161/circheartfailure.126.014184
Summarised from the published abstract; every number is checked against it