Coronary disease & ACSRandomised controlled trial
Management of Coronary Disease in Patients with Advanced Kidney Disease
- Randomised controlled trial
Authors' conclusion
Among patients with stable coronary disease, advanced chronic kidney disease, and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of death or nonfatal myocardial infarction.
Study context
- Population
- Patients with stable coronary disease, advanced CKD and moderate or severe ischemia on stress testing
- Participants
- 777 patients
- Comparison
- Initial invasive strategy vs initial conservative strategy
- Primary endpoint
- Death or nonfatal MI
Primary result
As reported in the abstract
median follow-up 2.2 years
Adjusted hazard ratio
1.01
95% CI 0.79–1.29
P = 0.95
Events by treatment group
Invasive strategy vs Conservative strategy
adjusted HR 1.01 (95% CI 0.79–1.29); P = 0.95
Secondary outcomes
Key secondary: death, nonfatal MI, or hospitalization for unstable angina, HF, or resuscitated cardiac arrest
- Results similar to the primary outcome
Safety
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Stroke | 3.76 (1.52–9.32) | P = 0.004 | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Management of Coronary Disease in Patients with Advanced Kidney Disease. N Engl J Med. Published 30 March 2020. doi:10.1056/nejmoa1915925
Summarised from the published abstract; every number is checked against it