Cardio-oncology & otherCohort study
Maternal and Pregnancy Outcomes Following Heart Transplantation in the United States
- Retrospective cohort study
- national database (Nationwide Readmissions Database 2010-2020)
Authors' conclusion
Delivery with history of HT is associated with significantly increased rates of SMM, preterm birth, and hospital readmission.
Study context
- Population
- Delivery hospitalizations in the US, Nationwide Readmissions Database 2010–2020
- Participants
- 19,399,521 deliveries
- Exposure
- Heart transplantation (HT) recipients vs no-HT
- HTn = 105
- Outcome
- SMM, nontransfusion SMM, cardiovascular SMM (cSMM) and preterm birth from delivery hospitalization
Main finding
As reported in the abstract
All SMM
Nontransfusion SMM
cSMM
Preterm birth
- All four comparisons HT vs No-HT
- P < 0.001
- Adjusted odds of severe maternal morbidity (SMM), HT vs No-HT
- 16-fold greater
- Adjusted odds of nontransfusion SMM, HT vs No-HT
- 28-fold greater
- Adjusted odds of cardiovascular SMM (cSMM), HT vs No-HT
- 38-fold greater
- Adjusted odds of preterm birth, HT vs No-HT
- 7-fold greater
Observational data: associations, not effects.
Further findings
| Outcome | HT | No-HT | adjusted HR (95% CI) | |
|---|---|---|---|---|
| Readmission · within 1 year following delivery | 26.9% | 3.8% | 6.03 (3.73–9.75) | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Original publication
Maternal and Pregnancy Outcomes Following Heart Transplantation in the United States. JACC Heart Fail. Published 4 October 2023. doi:10.1016/j.jchf.2023.08.018
Summarised from the published abstract; every number is checked against it