Cardio-oncology & otherCohort study
Maternal Risk of Cardiovascular Disease After Use of Assisted Reproductive Technologies
- Registry-based cohort study
- nationwide
- multinational (Denmark, Finland, Norway, Sweden)
Authors' conclusion
The findings of this study suggest that women who gave birth after ART were not at increased risk of CVD over a median follow-up of 11 years compared with those who conceived without ART.
Study context
- Population
- Individuals with a registered delivery in the national birth registries of Denmark, Finland, Norway and Sweden (1984–2015)97,474 (4%) after ART
- Participants
- 2,496,441 individuals
- Exposure
- Birth after ART vs birth without ART
- ARTn = 97,474
- Outcome
- Any CVD
- Follow-up
- Median 11 years
Main finding
As reported in the abstract
median follow-up 11 (IQR, 5-18) years
Adjusted hazard ratio
0.97
95% CI 0.91–1.02
ART vs No ART
adjusted HR 0.97 (95% CI 0.91–1.02)
- Rate of any cardiovascular disease (CVD) (overall)
- 153 per 100 000 person-years
Observational data: associations, not effects.
Further findings
| Outcome | adjusted HR (95% CI) | |
|---|---|---|
| MI | 0.80 (0.65–0.99) | |
| 0.512Adjusted hazard ratio (log scale) |
- MI: tendency for a modest reduction; no notable heterogeneity between countries
Ischemic heart disease, cerebrovascular disease, stroke, cardiomyopathy, HF, PE, DVT
- No significant differences with use of ART
Original publication
Maternal Risk of Cardiovascular Disease After Use of Assisted Reproductive Technologies. JAMA Cardiol. Published 1 September 2023. doi:10.1001/jamacardio.2023.2324
Summarised from the published abstract; every number is checked against it