Valvular & structural heart diseaseCohort study
MAUDE Registry Analysis of Pericardial Effusions Following Watchman and Amulet Left Atrial Appendage Occlusion
- MAUDE Registry Analysis
Authors' conclusion
These observations suggest that LPEs adversely affect patient outcomes and can cause significant morbidity. These findings highlight the importance of long-term surveillance of patients for complications after successful LAAO.
Study context
- Population
- Patients receiving an Amulet or Watchman left atrial appendage occlusion (LAAO) device who developed a pericardial effusion, reported in the Manufacturer and User Facility Device Experience database from FDA approval through December 2024pericardial effusion reports · Amulet 290 · Watchman 33
- Participants
- 290 vs 33
- Exposure
- Amulet vs Watchman
- Amuletn = 290
- Watchmann = 33
Main finding
As reported in the abstract
Late pericardial effusions (LPEs) among those who developed pericardial effusion
Observational data: associations, not effects.
Further findings
Intervention needed, Amulet implants, by effusion timing
Original publication
MAUDE Registry Analysis of Pericardial Effusions Following Watchman and Amulet Left Atrial Appendage Occlusion. JACC Adv. Published 15 May 2026. doi:10.1016/j.jacadv.2026.102789
Summarised from the published abstract; every number is checked against it