Heart failure & cardiomyopathies
Mean Corpuscular Haemoglobin Concentration and Outcomes in Heart Failure with Preserved Ejection Fraction
Authors' conclusion
Among HFpEF patients, hypochromia (i.e. MCHC ≤ 330 g/L) is independently associated with adverse clinical outcomes, especially when in the presence of co-morbidity renal dysfunction.
Study context
- Population
- Heart failure with preserved ejection fraction (HFpEF) participants from the Americas in TOPCAT with available baseline data
- Participants
- 1,747 participants
- Comparison
- Hypochromia vs non-hypochromia
- Hypochromian = 662
- Primary endpoint
- Composite of:
- CV mortality
- HF hospitalization
- Aborted cardiac arrest
Methodological detailsAmericas participants
- Americas participants
Primary result
As reported in the abstract
Primary endpoint
- Baseline hypochromia strongly associated with worse clinical outcomes
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Outcomes in eGFR < 60 mL/min per 1.73 m² (subgroup)Primary endpoint | 1.56 (1.23–1.98) | P < 0.001 | |
| Outcomes in eGFR < 60 mL/min per 1.73 m² (subgroup)Any-cause hospitalization | 1.43 (1.20–1.71) | P < 0.001 | |
| Outcomes in eGFR < 60 mL/min per 1.73 m² (subgroup)HF hospitalization | 1.40 (1.07–1.84) | P = 0.015 | |
| 0.512Hazard ratio (log scale) |
- Prevalence of baseline hypochromia
- 37.9% · 662
Outcomes in better renal function (subgroup)
- No significant association between hypochromia and these outcomes
Original publication
Mean Corpuscular Haemoglobin Concentration and Outcomes in Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 25 January 2023. doi:10.
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