Heart failure & cardiomyopathiesCohort study
Measuring long-term physical activity in patients with heart failure and its relation to health-related outcomes
- prospective observational trial
- reanalysed longitudinal data
Authors' conclusion
Long-term device-based physical activity monitoring showed that patients with heart failure met recommendations for MPA, yet vigorous activity exceeding 60% of heart rate reserve was almost entirely absent. Higher aerobic physical activity was associated with greater VO2max, lower fat mass, reduced systemic inflammation (C-reactive protein and interleukin-6), and lower NT-proBNP, but not with KCCQ, whereas only VPA, unlike MPA, was associated with higher VO2max and lower fat mass.
Study context
- Population
- Patients with heart failure, New York Heart Association (NYHA) Class I and Class II/III, monitored with a multisensory activity tracker over 12 monthspatients with heart failure · NYHA Class I 66 · NYHA Class II/III 90
- Participants
- 156 patients
- Exposure
- Associations between step count, moderate physical activity (MPA) and vigorous physical activity (VPA) and health-related outcomes
- NYHA In = 66
- NYHA II/IIIn = 90
Main finding
As reported in the abstract
| Group | MPA, min per week | VPA, min per week | steps per day |
|---|---|---|---|
| NYHA I | 225 (105;412) | 17 (7;44) | 8021 (6474;9910) |
| NYHA II/III | 167 (72;326) | 9 (4;23) | 6438 (5181;8627) |
Observational data: associations, not effects.
Further findings
VPA and VO2max (ml/kg/min)
- β (positive association)
- 3.815, 95% CI [1.430-10.186], P = .008
MPA and NT-proBNP (pg/ml)
- β (inverse association)
- −0.189, 95% CI [−0.353 to −0.025], P = .024
Step count and VO2max (ml/kg/min)
- β (positive association)
- 0.545, 95% CI [0.295-0.795], P < .001
Step count and fat mass (%)
- β (negative association)
- −1.058, 95% CI [−1.441 to −0.674], P < .001
Step count and C-reactive protein (mg/l)
- β (negative association)
- −0.057, 95% CI [−0.097 to −0.017], P = .005
Step count and interleukin-6 (pg/ml)
- β (negative association)
- −0.022, 95% CI [−0.043 to −0.001], P = .041
Absolute changes (Δ) associated with VPA · between baseline and 12 months
- improved VO2max (ml/kg/min)
- r = 0.197, P = .043
- reduced fat mass (%)
- r = 0.205, P = .014
Kansas City Cardiomyopathy Questionnaire (KCCQ)
- No relationship was found with KCCQ
Original publication
Summarised from the published abstract; every number is checked against it