Acute cardiac care & resuscitationDiagnostic or prognostic study
Measuring transient return of spontaneous circulation and rearrest after in-hospital cardiac arrest: a prospective validation study
- prospective validation study
- convenience sample
- blinded researcher reviewed defibrillator waveforms
Authors' conclusion
This validation study supports the use of a 60-s waveform-derived definition of transient ROSC with high accuracy compared to in-person identification.
Study context
- Population
- In-hospital cardiac arrest cases in a large metropolitan hospital system from April 2025 to January 2026, with retrievable defibrillator waveform dataincluded of 48 patients, 13 (38%) experienced at least one directly observed transient return of spontaneous circulation (ROSC) event
- Participants
- 34 cases
- Comparison
- a previously used definition of ROSC (at least 60 s of a potentially perfusing ECG rhythm without chest compressions) compared to the directly observed standard
Performance
As reported in the abstract
Transient ROSC identification, patient level
| Test or model | sensitivity | specificity | PPV | NPV |
|---|---|---|---|---|
| 60-s waveform-derived definition | 100% | 100% | 100% | 100% |
Further findings
| Outcome | 60-s waveform-derived definition | directly observed standard |
|---|---|---|
| Transient ROSC identification, event level | ||
| sensitivity | 86% (18/21) | Not reported in the abstract |
| false positives | two | Not reported in the abstract |
| PPV | 18/20, 90% | Not reported in the abstract |
Original publication
Measuring transient return of spontaneous circulation and rearrest after in-hospital cardiac arrest: a prospective validation study. Resuscitation. Published 20 May 2026. doi:10.1016/j.resuscitation.2026.111140
Summarised from the published abstract; every number is checked against it