Acute cardiac care & resuscitation
Mechanical circulatory support devices vs. standard medical therapy for treatment of myocardial infarction complicated by cardiogenic shock: a network meta-analysis
Pooled result · MortalityResult — go to the resultRelative risk 0.81Authors' conclusion
Impella® support in AMICS was associated with a long-term survival benefit. Impella®, ECMO, and TandemHeart® use were associated with increased morbidity.
Study context
- Population
- Acute myocardial infarction complicated by cardiogenic shock (AMICS)
- Participants
- 1,907 participants · 18 randomized controlled trials (RCTs)
- Comparison
- Mechanical circulatory support (MCS) devices vs. standard medical therapy
- Outcome
- Mortality
- Follow-up
- 6-12 month
Methodological detailsexclusively randomized controlled trials (RCTs)
- Exclusively randomized controlled trials (RCTs)
Pooled result
As reported in the abstract
Relative risk
0.81
P < 0.05
Safety
| Outcome | RR | P value |
|---|---|---|
| Renal replacement therapy, limb complications, major bleeding (Impella®)Impella® vs standard medical therapy · renal replacement therapy | 1.6 | P = 0.02 |
| Renal replacement therapy, limb complications, major bleeding (Impella®)Impella® vs standard medical therapy · limb complications | 4.8 | P = 0.02 |
| Renal replacement therapy, limb complications, major bleeding (Impella®)Impella® vs standard medical therapy · major bleeding | 2.0 | P = 0.004 |
| Vascular complications and major bleeding (ECMO)ECMO vs standard medical therapy · vascular complications | 3.1 | P = 0.003 |
| Vascular complications and major bleeding (ECMO)ECMO vs standard medical therapy · major bleeding | 2.4 | P = 0.0001 |
| Limb complications (TandemHeart®)TandemHeart® vs standard medical therapy | 19 | P = 0.05 |
Original publication
Mechanical circulatory support devices vs. standard medical therapy for treatment of myocardial infarction complicated by cardiogenic shock: a network meta-analysis. Eur Heart J Qual Care Clin Outcomes. Published 30 July 2025. doi:10.
Summarised from the published abstract; every number is checked against it