Medication Adherence in Hypertension: A Cluster Randomized Clinical Trial
Primary result · Change in PDCResult — go to the resultAdjusted difference −0.15 percentage point 95% CI −4.06 to 3.76Authors' conclusion
In this pragmatic trial, an intervention that combined team-based primary care with automated identification of patients with antihypertensive medication nonadherence did not lead to improvements in adherence or blood pressure.
Study context
- Population
- Adults with uncontrolled hypertension and low medication adherence (proportion of days covered (PDC) <80%), 10 primary care sites in New York, 2022–2024
- Participants
- 1,726 adults
- Comparison
- Multicomponent adherence intervention vs usual care
- Primary endpoint
- Change in proportion of days covered (PDC) from baseline
- Follow-up
- 12 months
Methodological detailspragmatic, 2-arm, cluster randomized, 10 primary care sites
- Pragmatic
- 2-arm
- Cluster randomized
- 10 primary care sites
Primary result
Change in PDC
Adjusted difference
−0.15 percentage point
95% CI −4.06 to 3.76
Change by group
Intervention
18.5
mean absolute change · SD 41.1 · percentage points
Usual care
18.2
mean absolute change · SD 40.9 · percentage points
Intervention vs Usual care
adjusted difference −0.15 percentage point (95% CI −4.06 to 3.76)
As reported in the abstract
Further findings
Mean
| Outcome | Intervention | Usual care |
|---|---|---|
| PDC at 12 months | 51.1% (SD 39.5%) | 53.1% (SD 39.6%) |
Change in SBP; becoming adherent (PDC ≥80%) · 12 months
- Similar between groups
Original publication
Medication Adherence in Hypertension: A Cluster Randomized Clinical Trial. JAMA Cardiol. Published 1 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it