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Valvular & structural heart diseaseCohort study

Medium-term outcomes and prognostic factors after transcatheter paravalvular leak closure: an international prospective multicentre registry

EuroInterventionPublished

  • international prospective multicentre registry
  • consecutive symptomatic patients
  • 24 European centres
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Authors' conclusion

Transcatheter PVL closure offers a durable therapeutic option for high-risk patients when early clinical success is achieved. Mitral valve involvement, mechanical prostheses, and haemolytic anaemia remain key predictors of poor outcomes over a 2-year follow-up.

Study context

Population
Consecutive symptomatic patients undergoing transcatheter paravalvular leak (PVL) closure across European centres between 2017 and 2019symptomatic patients who underwent 237 procedures
Participants
213 patients

Main finding

As reported in the abstract

Survival without the need for surgical reintervention · 2 years

Survival rate without the need for surgical reintervention

66.1% (95% confidence interval [CI]: 60.1-72.7)

Observational data: associations, not effects.

Further findings

Adverse outcomes, by absence of clinical success at 1 month

Comparisonhazard ratio (95% CI)P value
Absence of clinical success at 1 month · strongest predictor of adverse outcomes5.00 (2.70–9.09)P = 0.001

Independent risk factors for adverse outcomes during follow-up (multivariate analysis)

Mitral PVL, mechanical valves, and haemolytic anaemia identified as independent risk factors

Baseline and procedural characteristics

Mean age
68±11 years
Median European System for Cardiac Operative Risk Evaluation (EuroSCORE) II
6 (interquartile range [IQR] 4-10)
Mitral valve PVL
64.6% of cases
Mechanical prostheses
53.3%
Heart failure
89.5%
Haemolytic anaemia
49.8%
Transapical approach
6.8% of cases

Technical and clinical success

Technical success
87.3% of procedures
Clinical success at 1 month
70.5% of patients

Original publication

Medium-term outcomes and prognostic factors after transcatheter paravalvular leak closure: an international prospective multicentre registry. EuroIntervention. Published 19 January 2026. doi:10.4244/eij-d-25-00798
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Summarised from the published abstract; every number is checked against it