Arrhythmias & electrophysiology
MEPPC Syndrome: A Systematic Review and State-of-the-Art Paper
Study context
- Population
- Multifocal ectopic Purkinje-related premature contractions (MEPPC) syndrome
Methodological detailsstate-of-the-art paper
- State-of-the-art paper
Pooled result
As reported in the abstract
- Caused by SCN5A gain-of-function mutations in the cardiac Na+ channel (Nav1.5), altering cardiomyocyte action potentials
- Diagnostic hallmark: high daily burden of multifocal PVCs on 24-hour dynamic ECG, with repetitive ventricular arrhythmias; may cause reversible PVC-induced cardiomyopathy (LV dilation with systolic dysfunction)
- Disappearance of arrhythmias on stress test and inefficacy of catheter ablation support suspicion; genetic testing and electrophysiological studies confirm diagnosis
- Management mainly class I antiarrhythmics (flecainide, quinidine), which may reduce ventricular arrhythmias and symptoms
Original publication
MEPPC Syndrome: A Systematic Review and State-of-the-Art Paper. Circ Arrhythm Electrophysiol. Published 29 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →