Valvular & structural heart diseaseMeta-analysis
Meta-Analysis of Dedicated vs Off-Label Transcatheter Devices for Native Aortic Regurgitation
- Systematic review and meta-analysis
- random-effects model
Authors' conclusion
Dedicated TAVR devices for native AR show superior device success and reduced mortality, residual AR, and reintervention rates compared with off-label devices.
Study context
- Population
- High surgical risk patients with pure severe native aortic regurgitation (AR) undergoing transcatheter aortic valve replacement (TAVR)
- Participants
- 2,162 patients · 34 studies
- Comparison
- Dedicated vs off-label TAVR devices
- Outcome
- All-cause mortality
- Follow-up
- 30 days
Pooled result
As reported in the abstract
P < 0.01
Further pooled results
Device success
P < 0.01
Residual AR ≥ moderate · 30 days
P = 0.03
Reintervention · 30 days
P < 0.01
All-cause mortality · 1 year
P < 0.01
Safety
Valve embolization/migration · 30 days
P < 0.01
Pacemaker implantation · 30 days
P < 0.01
Original publication
Meta-Analysis of Dedicated vs Off-Label Transcatheter Devices for Native Aortic Regurgitation. JACC Cardiovasc Interv. Published 20 November 2024. doi:10.1016/j.jcin.2024.08.042
Summarised from the published abstract; every number is checked against it