Prevention & lipidsCohort study
Metabolic disorders mediate the relation of miscarriage with cardiovascular diseases
- Prospective cohort study
- causal mediation analysis
Authors' conclusion
Hypertension, DM, and lipoprotein metabolism disorders mediated the association between miscarriage and various cardiovascular outcomes in later life. In particular, hypertension mediated a large proportion of the relationship between miscarriage and atherosclerotic CVD.
Study context
- Population
- Ever-gravid women in the UK Biobank without established metabolic disorders or CVD, followed from 2007–2010 baseline to December 2020
- Participants
- 163,283 women
- Exposure
- Mediation by hypertension, diabetes mellitus (DM) and lipoprotein metabolism disorders of miscarriage–CVD association
- Outcome
- Proportion of the association of miscarriage and stillbirth with CHD, stroke, HF, AF and composite outcomes mediated by hypertension, DM and lipoprotein metabolism disorders
Main finding
As reported in the abstract
Proportion mediated
- Hypertension, history of miscarriage → incident coronary heart disease (CHD)
- 11.1% (95% CI 3.7-18.5%)
- Hypertension, recurrent miscarriages → incident CHD
- 9.5% (4.1-14.8%)
- Lipoprotein metabolism disorders, recurrent miscarriages → incident CHD
- 8.4% (2.5-14.3%)
- DM, recurrent miscarriages → incident CHD
- 1.7% (0.5-2.9%)
- Hypertension, recurrent miscarriages → incident stroke
- 10.7% (0.2-21.1%)
- Hypertension, history of miscarriage → atherosclerotic CV event
- 15.5%
- Hypertension, recurrent miscarriages → atherosclerotic CV event
- 9.4%
Observational data: associations, not effects.
Original publication
Metabolic disorders mediate the relation of miscarriage with cardiovascular diseases. Eur J Prev Cardiol. Published 6 November 2023. doi:10.1093/eurjpc/zwad347
Summarised from the published abstract; every number is checked against it