Heart failure & cardiomyopathiesCohort study
Metabolic Dysfunction and Incidence of Heart Failure Subtypes Among Black Individuals: The Jackson Heart Study
- Prospective cohort study
Authors' conclusion
Metabolic syndrome severity was associated with both HF subtypes among Black individuals
Study context
- Population
- Black Jackson Heart Study participants without heart failure (HF) (mean age 54.4 years, 63.8% women, 37.2% with metabolic syndrome (MetS))
- Participants
- 4,069 participants
- Exposure
- MetS and MetS severity vs no MetS / lowest severity quartile
- Outcome
- Incident HF hospitalization, including HFpEF and HFrEF
- Follow-up
- Median 12 years
Main finding
As reported in the abstract
Incident HF
Hazard ratio (95% CI)
MetS vs No MetS
2.07(1.64–2.61)
MetS-Z-WC Q4 vs MetS-Z-WC Q1
2.35(1.67–3.30)
- Participants developing HF
- 319
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident HF by subtype (MetS-Z-WC Q4 vs Q1) · median 12 years — MetS-Z-WC Q4 vs MetS-Z-WC Q1 · HFpEF | 4.94 (2.67–9.14) | |
| Incident HF by subtype (MetS-Z-WC Q4 vs Q1) · median 12 years — MetS-Z-WC Q4 vs MetS-Z-WC Q1 · HFrEF | 1.69 (1.06–2.70) | |
| 0.10.31310Hazard ratio (log scale) |
- Incident HF by subtype (MetS-Z-WC Q4 vs Q1) — HF with preserved ejection fraction (HFpEF) events
- 157
- Incident HF by subtype (MetS-Z-WC Q4 vs Q1) — HF with reduced ejection fraction (HFrEF) events
- 149
- Incident HF by subtype (MetS-Z-WC Q4 vs Q1) — HF of unknown type
- 13
Subclinical cardiac remodelling (echocardiography, hs-cTnI, BNP)
- MetS severity associated with subclinical cardiac remodelling
Original publication
Metabolic Dysfunction and Incidence of Heart Failure Subtypes Among Black Individuals: The Jackson Heart Study. Eur J Heart Fail. Published 3 September 2024. doi:10.1002/ejhf.3447
Summarised from the published abstract; every number is checked against it