Arrhythmias & electrophysiologyCohort study
Microembolizations in the arterial cerebral circulation during atrial fibrillation ablation: cryoballoon technique advantages and neurocognitive safety—results of a prospective observational study
- Prospective observational study
- single-centre
Authors' conclusion
Our observations confirm that neurocognitive abilities are not affected either 24 h or 3 months after AF ablation using the CB technique.
Study context
- Population
- Patients undergoing cryoballoon atrial fibrillation (AF) ablation at a German centre, February 2021–August 2022median age 65.5 years
- Participants
- 100 patients
- Exposure
- Paroxysmal AF vs persistent AF
- Outcome
- Micro-embolic signals (MESs) on transcranial Doppler during ablation; neurocognitive status (CERAD Plus battery)
- Follow-up
- Pre- and post-procedure and at 3 months
Main finding
As reported in the abstract
MESs during ablation
- Total MESs observed
- 19 698
- Gaseous origin
- 80%
- Solid origin
- 20%
- Median MES per patient, total
- 130 (IQR: 92-256)
- Median MES per patient, bilateral recordings (36%)
- 298 (IQR: 177-413)
- Median MES per patient, unilateral recordings (64%)
- 110 (IQR: 71-130)
Observational data: associations, not effects.
Safety
Cognitive decline (11 neuropsychological tests, CERAD Plus) · post-procedure and at 3 months
- None of the 11 tests showed cognitive decline
- 0
Original publication
Microembolizations in the arterial cerebral circulation during atrial fibrillation ablation: cryoballoon technique advantages and neurocognitive safety—results of a prospective observational study. Europace. Published 24 August 2024. doi:10.1093/europace/euae222
Summarised from the published abstract; every number is checked against it