Microvascular obstruction identifies a subgroup of patients who benefit from stem cell therapy following ST-elevation myocardial infarction
Primary result · LVEF recovery in patients with MVOResult — go to the resultAbsolute difference 2.7%Authors' conclusion
The presence of MVO on cardiac MRI following STEMI identifies a subgroup of patients who benefit from intracoronary stem cell therapy.
Study context
- Population
- Patients with anterior ST-elevation myocardial infarction (STEMI) treated with primary PCI and stenting, with cardiac MRI (TIME and its pilot, BONAMI, SWISS-AMI trials)327 with paired 1-year imaging
- Participants
- 356 patients
- Comparison
- Intracoronary autologous BMCs vs placebo/control, by presence of microvascular obstruction (MVO)
- Primary endpoint
- Recovery of LVEF by cardiac MRI, by presence of MVO
- Follow-up
- 12 months
Methodological detailsmulticentre
- Multicentre
Primary result
LVEF recovery in patients with MVO
Absolute difference
2.7%
P < 0.05
As reported in the abstract
Further findings
Baseline LVEF, infarct size and left-ventricular (LV) volumes, MVO vs no MVO
- Patients with MVO had reduced LVEF and much greater infarct size and LV volumes than those without MVO
- P < 0.01
Original publication
Microvascular obstruction identifies a subgroup of patients who benefit from stem cell therapy following ST-elevation myocardial infarction. Am Heart J. Published 14 February 2023. doi:10.
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